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Prof. Albert Pinhasov

Albert Pinhasov is a Professor in the Department of Molecular Biology and the Dr. Miriam and Sheldon G. Adelson School of Medicine, and has served as the Head of the Institute for Personalized Medicine since 2025. His research focuses on Molecular Psychiatry and Psychopharmacology, with an emphasis on understanding the molecular mechanisms of mental disorders and the relationship between the development of psychiatric conditions and stress sensitivity.

Critical role of personality and stress in drug dependency

This study investigates how stress and personality traits influence vulnerability to drug addiction. Using a mouse model of dominance and submissiveness, we identify genomic and hormonal signatures underlying differential responses to drugs, aiming to develop personalized prognostic tools for addiction risk.
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Molecular biology of depressive and anxiety disorders

This study explores the biological mechanisms underlying depression and anxiety through animal models and human research. By comparing stress-resilient and vulnerable mouse strains, we identify biomarkers and assess their relevance to human psychiatric disorders, including MDD and bipolar disorder.
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Influence of resilience and sensitivity to stress on ageing and related cognitive impairments

Exploring how stress, depression, and personality traits contribute to age-related cognitive decline, this research uses stress-resilient and vulnerable mouse models to identify underlying molecular mechanisms and genes, aiming to support early diagnosis and prevention of cognitive impairment in humans.
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Assessing the link between the gut microbiome and behavior using a mouse model of dominance and submissiveness

Gut microbiome composition influences brain function and behavior via neural, endocrine, and immune pathways. Using dominance and submissiveness mouse models, we show microbiome differences drive depressive-like behavior, supporting targeted microbiome modulation as a potential therapeutic strategy for behavioral disorders.
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Identifying at-risk populations for maladaptive response to prenatal stress

Prenatal stress shapes lifelong vulnerability to behavioral disorders. Using mouse models of stress resilience and susceptibility, we show that offspring of stressed, vulnerable mothers exhibit heightened stress responses and depressive traits, and identify placental glucocorticoid receptor pathways as targets for early diagnosis.
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ALOS4: A Novel Cyclic Peptide with Anti-Cancer and Anti-Inflammatory Properties

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ALOS4 is a cyclic peptide with potent anti-cancer and anti-inflammatory effects. It inhibits tumor growth, reduces pro-inflammatory cytokines, modulates macrophage activity, and suppresses interferon-response pathways without observed toxicity.
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