Project Overview
We investigate how gut microbiota influences stress vulnerability, metabolic regulation, and behavioral phenotypes through interactions along the gut–brain axis. Using a unique mouse model of dominance and submissiveness, we study microbiome-associated neural and immune mechanisms that contribute to resilience or susceptibility to stress-related neuropsychiatric disorders. Our goal is to identify biomarkers, therapeutic targets, and microbiome-based intervention strategies for stress-related neuropsychiatric disorders.
Research Focus
- Gut-Brain Axis
- Neuroimmunology
- Stress Vulnerability
- Behavioral Psychiatry
Experimental Approaches
- Behavioral mouse models
- Microbiome profiling
- Cytokine analysis
- SCFA and metabolomic profiling
- Gut permeability assessment
Clinical Relevance
- Biomarker discovery
- Microbiome-targeted therapeutic strategies
- Prediction and stratification of stress-related neuropsychiatric disorders
Principal Investigator: Prof. Albert Pinhasov
Behavioral and Molecular Psychiatry Lab
Recent publications:
https://pubmed.ncbi.nlm.nih.gov/40634281/
Agranyoni, O., Sur, D., Amidror, S., Shidlovsky, N., Bagaev, A., Yissachar, N., Pinhasov, A., & Navon-Venezia, S. Colon impairments and inflammation driven by an altered gut microbiota leads to social behavior deficits rescued by hyaluronic acid and celecoxib. BMC medicine. 2024 Apr 29;22(1):182.
https://pubmed.ncbi.nlm.nih.gov/38685001/
Agranyoni O, Meninger-Mordechay S, Uzan A, Ziv O, Salmon-Divon M, Rodin D, Raz O, Koman I, Koren O, Pinhasov A, Navon-Venezia S. Gut microbiota determines the social behavior of mice and induces metabolic and inflammatory changes in their adipose tissue. NPJ biofilms and microbiomes. 2021 Mar 19;7(1):1-4.