Dr. Elemeleh Nesher

Dr. Elimelech Nesher became a Department Member of Ariel University in 2018.

He made his Post-Doctoral Fellowship in the Cell Stress Department of Roswell Park Cancer Institute (Buffalo, NY) working with a large panel of cell-based assays designed to detect modulators of a variety of signaling pathways including Multiple drug resistance (MDR), interferon response genes, p53, NF-kB, heat shock, hypoxia and other types of stress responses.

Dr. Nesher is the Head of the Tumor Cells Biology Lab. His research is mainly concentrated on the biological role of histone chaperones in chromatin maintenance and cancer metabolism.

The ketogenic diet alters cancer cell metabolism by promoting ketone body utilization under low-glucose conditions. This study examines their dual role in signaling and energy supply, and their impact on breast cancer cell oncogenicity, survival, proliferation, and migration.
This project investigates how cancer cells adapt to glucose deprivation by shifting to oxidative metabolism. It focuses on metabolically flexible subpopulations, associated DNA damage and repair mechanisms, and chromatin changes that may support survival and resistance under nutrient stress conditions.
ALOS4 is a cyclic peptide with potent anti-cancer and anti-inflammatory effects. It inhibits tumor growth, reduces pro-inflammatory cytokines, modulates macrophage activity, and suppresses interferon-response pathways without observed toxicity.