This study investigates how stress and personality traits influence vulnerability to drug addiction. Using a mouse model of dominance and submissiveness, we identify genomic and hormonal signatures underlying differential responses to drugs, aiming to develop personalized prognostic tools for addiction risk.

This study explores the biological mechanisms underlying depression and anxiety through animal models and human research. By comparing stress-resilient and vulnerable mouse strains, we identify biomarkers and assess their relevance to human psychiatric disorders, including MDD and bipolar disorder.

Exploring how stress, depression, and personality traits contribute to age-related cognitive decline, this research uses stress-resilient and vulnerable mouse models to identify underlying molecular mechanisms and genes, aiming to support early diagnosis and prevention of cognitive impairment in humans.

Prenatal stress shapes lifelong vulnerability to behavioral disorders. Using mouse models of stress resilience and susceptibility, we show that offspring of stressed, vulnerable mothers exhibit heightened stress responses and depressive traits, and identify placental glucocorticoid receptor pathways as targets for early diagnosis.