Mishel Sosenko

This study found that prenatal cannabis exposure affects offspring differently based on their temperament. “Resilient” mice became more anxious, while “sensitive” mice became more social and less anxious. The findings highlight that the effects of cannabis during pregnancy are complex and depend on individual personality traits.
Our study found that improving a mother’s gut health after birth—using a simple supplement—can lead to calmer, more social, and metabolically healthier offspring. The effect was especially strong in males, showing how a mother’s gut can shape her babies’ development in surprising ways.
Our researchers developed a new lab model that mimics a patient’s stomach cancer more accurately by combining tumor cells with surrounding support cells. This approach better reflects how tumors behave in the body and may help predict which treatments will work for each individual patient.
Our researchers found that social status in mice (dominant vs. submissive) is linked to differences in brain activity. These differences affect how brain regions communicate and may influence memory, learning, and the ability to recognize new things. Stress sensitivity also plays an important role.
This study shows that gut bacteria can influence social behavior, body weight, and inflammation. Mice with different microbiomes displayed distinct social traits—dominant or submissive. Transferring gut bacteria between mice also transferred these traits, highlighting a strong connection between gut health, metabolism, and behavior.
This study investigates how stress and personality traits influence vulnerability to drug addiction. Using a mouse model of dominance and submissiveness, we identify genomic and hormonal signatures underlying differential responses to drugs, aiming to develop personalized prognostic tools for addiction risk.
This study explores the biological mechanisms underlying depression and anxiety through animal models and human research. By comparing stress-resilient and vulnerable mouse strains, we identify biomarkers and assess their relevance to human psychiatric disorders, including MDD and bipolar disorder.
Exploring how stress, depression, and personality traits contribute to age-related cognitive decline, this research uses stress-resilient and vulnerable mouse models to identify underlying molecular mechanisms and genes, aiming to support early diagnosis and prevention of cognitive impairment in humans.
Gut microbiome composition influences brain function and behavior via neural, endocrine, and immune pathways. Using dominance and submissiveness mouse models, we show microbiome differences drive depressive-like behavior, supporting targeted microbiome modulation as a potential therapeutic strategy for behavioral disorders.
Prenatal stress shapes lifelong vulnerability to behavioral disorders. Using mouse models of stress resilience and susceptibility, we show that offspring of stressed, vulnerable mothers exhibit heightened stress responses and depressive traits, and identify placental glucocorticoid receptor pathways as targets for early diagnosis.