Scientists have long suspected a connection between gut health and how we behave socially - and this study brings us one step closer to understanding it. Using a unique mouse model, researchers explored how gut bacteria influence whether a mouse becomes dominant (Dom) or submissive (Sub).
Breast cancer is the leading cause of cancer-related deaths among women, and current treatments don't always work the same for everyone. One big challenge is that doctors often don't know in advance which chemotherapy will be most effective for each patient.
A popular diet called the ketogenic diet (high fat, low carbs) causes the body to produce ketone bodies, which are natural energy sources. One of them, β-hydroxybutyrate (βHb), may affect how cancer cells behave.
One of our key tools is the assembloid model—a cutting-edge 3D culture system that mimics the complexity of human tumors by incorporating cancer cells with supporting stromal and immune components. This model enables us to test drug responses in a patient-specific context, offering a powerful platform for predicting treatment outcomes and guiding personalized therapeutic decisions.
Cancer cells are known to consume higher amounts of glucose (Warburg effect or aerobic glycolysis) associated with upregulated expression of genes involved in glucose metabolism. In our experimental work with glucose metabolism, we identified a previously undescribed subpopulation that is able to survive in the absence of glucose supply.
One of our key tools is the assembloid model—a cutting-edge 3D culture system that mimics the complexity of human tumors by incorporating cancer cells with supporting stromal and immune components. This model enables us to test drug responses in a patient-specific context, offering a powerful platform for predicting treatment outcomes and guiding personalized therapeutic decisions.
