Dr. Igor Koman

β-hydroxybutyrate as a regulator of Breast Cancer cells metabolism and oncogenicity

Dr. Elemeleh Nesher Dr. Igor Koman

The ketogenic diet alters cancer cell metabolism by promoting ketone body utilization under low-glucose conditions. This study examines their dual role in signaling and energy supply, and their impact on breast cancer cell oncogenicity, survival, proliferation, and migration.

Patient-Derived Tumor Models Incorporating the Tumor Microenvironment

Dr. Gabriela Rozic Dr. Igor Koman

This project develops patient-derived tumor models that integrate epithelial, stromal, and immune components to better reflect human tumor biology. The platform preserves tumor heterogeneity and enables more accurate prediction of therapeutic responses and personalized treatment strategies across cancer types.

Metabolic Adaptation of Cancer Cells to Glucose Deprivation

Dr. Elemeleh Nesher Dr. Igor Koman

This project investigates how cancer cells adapt to glucose deprivation by shifting to oxidative metabolism. It focuses on metabolically flexible subpopulations, associated DNA damage and repair mechanisms, and chromatin changes that may support survival and resistance under nutrient stress conditions.

Dr. Igor Koman

β-hydroxybutyrate as a regulator of Breast Cancer cells metabolism and oncogenicity

Dr. Elemeleh Nesher Dr. Igor Koman

Patient-Derived Tumor Models Incorporating the Tumor Microenvironment

Dr. Gabriela Rozic Dr. Igor Koman

Metabolic Adaptation of Cancer Cells to Glucose Deprivation

Dr. Elemeleh Nesher Dr. Igor Koman

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