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Dr. Igor Koman

Igor Koman MD, PhD, D.Sci, has both clinical and research experience in clinical oncology and clinical pharmacology. He is a pioneer in the field of personalized medicine and was instrumental in its genesis. In 2015, he founded the Institute for Personalized Medicine and served as its head until 2025. As the head of the Institute, Dr. Koman focused his efforts on building and supporting a strong scientific agenda and inspiring an exceptional team of dedicated scientists. His personal interests focus on developing personalized target-based therapeutic strategies to cure cancer.

Patient-Derived Tumor Models Incorporating the Tumor Microenvironment

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This project develops patient-derived tumor models that integrate epithelial, stromal, and immune components to better reflect human tumor biology. The platform preserves tumor heterogeneity and enables more accurate prediction of therapeutic responses and personalized treatment strategies across cancer types.
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β-hydroxybutyrate as a regulator of Breast Cancer cells metabolism and oncogenicity

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The ketogenic diet alters cancer cell metabolism by promoting ketone body utilization under low-glucose conditions. This study examines their dual role in signaling and energy supply, and their impact on breast cancer cell oncogenicity, survival, proliferation, and migration.
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Metabolic Adaptation of Cancer Cells to Glucose Deprivation

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This project investigates how cancer cells adapt to glucose deprivation by shifting to oxidative metabolism. It focuses on metabolically flexible subpopulations, associated DNA damage and repair mechanisms, and chromatin changes that may support survival and resistance under nutrient stress conditions.
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