Translational and personalized oncology

Translational and personalized oncology focuses on bridging scientific discovery with its application in cancer care. This field aims to translate insights from laboratory research into clinically relevant strategies tailored to the individual characteristics of each patient.

Our work integrates molecular profiling, biological research, and clinical understanding to explore personalized approaches to cancer treatment. Over time, our efforts have contributed to identifying potential biomarkers, studying tumor biology, and supporting the development of targeted therapeutic strategies.

Research activities in this area have also included involvement in anti-cancer drug development, with the goal of improving treatment precision while reducing side effects. In parallel, we have explored approaches for assessing drug response prior to treatment, aiming to better understand how different cancers may react to specific therapies.

In addition, our research has examined cancer metabolism and its impact on tumor behavior, including studies on metabolic factors  and conditions of nutrient availability, and how these may influence cancer cell activity and oncogenic potential.

Through a multidisciplinary perspective, this field continues to evolve, contributing to the broader effort of making cancer care more precise, adaptive, and patient-centered.

This project develops patient-derived tumor models that integrate epithelial, stromal, and immune components to better reflect human tumor biology. The platform preserves tumor heterogeneity and enables more accurate prediction of therapeutic responses and personalized treatment strategies across cancer types.
The ketogenic diet alters cancer cell metabolism by promoting ketone body utilization under low-glucose conditions. This study examines their dual role in signaling and energy supply, and their impact on breast cancer cell oncogenicity, survival, proliferation, and migration.
This project investigates how cancer cells adapt to glucose deprivation by shifting to oxidative metabolism. It focuses on metabolically flexible subpopulations, associated DNA damage and repair mechanisms, and chromatin changes that may support survival and resistance under nutrient stress conditions.
ALOS4 is a cyclic peptide with potent anti-cancer and anti-inflammatory effects. It inhibits tumor growth, reduces pro-inflammatory cytokines, modulates macrophage activity, and suppresses interferon-response pathways without observed toxicity.